Novel structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties

Abstract

This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are as indicated below in each of said analogs: 1. R1=COCH3, R2=R3=R4=H, R5=COOH or R1, =R3=R4=H, R2=COCH3, R5=COOH 2. R1=R2=COCH3, R3=R4=H, R5=COOH 3. R1=COC5H4N, R2=R3=R4=H, R5=COOH 4. R1=COCH2NH2.HC1, R2=R3=R4=H, R5=COOH 5. R1=COCH2(CH3)NH2.HC1, R2=R3=R4=H, R5=COOH 6. R1=COCH:CHC6H2(OCH3)3, R2=R3=R4=H, R5=COOCH3 7. R1 & R2=S02, R3=R4=H, R5=COOH 8. R1=R2=R3=R4=H, R5=CONH2 9. R1=R2=R3=R4=H, R5=CONHC6H5 10. R1=R2=R3=R4=H, R5=CONHCH2CH2NH2 11. R1=R2=R3=R4=H, R5=CON(CH2CH2)2NH 12. R1=R2=R3=R4=H, R5=CONHCH2CH20H 13. R1=R2=R3=R4=H, R5=COOCH3 14. R1=R2=COCH3, R3=R4=H, R5=COOCH3 15. R1=R2=H, R3 & R4=0, R5=COOCH3 16. R1=R2=COCH3, R3 & R4=0, R5=COOCH3 17. R1=R2=H, R3 & R4=0, R5=COOH 18. R1=R2=COCH3, R3 & R4=0, R5=COOH 19. R1 & R2=S02, R3 & R4=0, R5=COOH 20. R1=R2=H, R3 & R4=0, R5=CONH2 21. R1=R2=R3=H, R4=OH, R5=CONH2 22. R1=R2=R3=H, R4=OH, R5=COOCH3 23. R1=R2=R3=R4=H, R5=CH20H 24. R1=R2=R3=R4=H, R5=CHO 25. R1=R2=R3=R4=H, R5=COOCOC6H2(OCH3)3 26. R1=R2=R3=H, R4 & R5=OCO. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compound are also within the scope of this invention.

Dependencies are inferred from the claim text.