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US 2007/0167519 A1Published application
Novel Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof
AssigneesGalderma Research & Development, Cnrs
InventorsJacques Eustache, Pierre Weghe, Vincent Rodeschini, Celine Tarnus
Life of this patent
Estimating the term…
Abstract
Novel derivatives of fumagalone have the general formula (I): and are useful angiogenes is inhibitors; these can be formulated into pharmaceutical compositions suited for human or veterinary medicine, or can be formulated into cosmetic compositions.
Claims11
A compound having the following general formula (I):
- in which:
- R1 is a radical of structure (a) or of structure (b):
- wherein R5, R6 and R7 are as defined below;
- R2 is a lower alkyl radical having 1 to 5 carbon atoms;
- R3 is a lower alkyl radical having 1 to 5 carbon atoms;
- R4 is a radical of structure (c), bound by a single bond to the cyclohexane from which it depends:
- or R4 is an oxygen atom bound by a double bond to the cyclohexane from which it depends;
- R5 is a hydrogen atom or a methyl radical or a trifluoromethyl radical;
- and
- R6 and R7 represent, independently of one another, a hydrogen atom or a trifluoromethyl radical, or salt or isomer thereof.
7 more elements
The cosmetic composition as defined by claim 9, comprising from 0.0001 wt. % to 3 wt. % relative to the total weight of the composition of said at least one compound.
Dependencies are inferred from the claim text.