Medicinal composition for prevention or treatment of overactive bladder accompanying nervous disorder

A method for the prevention or treatment of overactive bladder accompanied with neurogenic disorders, which comprises administering an effective amount of an indoline derivative represented by a formula:

• wherein in the formula, R represents a saturated or unsaturated aliphatic acyl group which may have as a substituent a hydroxy group, a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, a cycloalkyl group, an aryl group or one or more halogen atoms;
• a hydroxy lower alkyl group;
• an aliphatic acyloxyalkyl group;
• a lower alkyl group which has as a substituent a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, an aryl-substituted lower alkoxycardonyl group, a carboarloyl group, a mono or di (lower alkyl)-substituted carbarnoyl group or a cyano group;
• an aromatic acyl group which may have as a substituent one or more halogen atoms;
• a furoyl group or a pyridylcarbonyl group;
• R1 represents a cyano group or a carbamoyl group;
• R2 represents a lower alkyl group which may have as a substituent a cyano group, an aryl group or one or more halogen atoms;
• or a pharmaceutically acceptable salt thereof.