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OwnerTakayuki Maruyama, Michiyoshi Kobayashi +3inventors
InventorsTakayuki Maruyama, Michiyoshi Kobayashi, Shigeyuki Nonaka, Hiroki Okada, Takashi Konemura
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A preventive and/or a remedy for urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence which comprises a combination of compound having antagonism to EP1 with another compound having antagonism to EP3 each selected from among prostaglandin E2 receptors. The combination of an EP1 antagonist with an EP3 antagonist is useful in preventing and/or treating urinary tract diseases with symptoms such as urgency of urination, bladder pain, frequent urination or urine incontinence, because of showing effect of improving urine retaining ability, improving bladder compliance, relieving hypertonic detrusor muscle and normalizing bladder perception.
1-16. (canceled)
A method for preventing and/or treating urinary tract disease, which comprises administering an effective amount of a medicament comprising a combination of EP1, antagonist and EP3 antagonist to a mammal.
19-20. (canceled)
Dependencies are inferred from the claim text.