US 2007/0167498 A1 · Carboxylic acid compounds

Abstract

The present invention relates to a carboxylic acid compound of formula (I): wherein R1 is H, alkyl; m is 2, 3; n is 0-2; R2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH2—O-Cyc1, —CH2-Cyc2, -L-Cyc3; R3a and R3b each independently is hydrogen, alkyl or taken together form tetrahydro-2H-pyran; a pharmaceutically acceptable salt thereof, a method for producing a process of the preparation thereof and a pharmaceutical agent comprising the same as an active ingredient. The compound of formula (I) have an antagonizing activity against PGE2 receptor, specifically EP3 receptor which is subtype thereof, and are useful for the prevention and/or treatment of itching, pain, urinary disturbance or stress disease.

Claims12

Dependent claims

A carboxylic acid compound of formula (I):

wherein R1 is hydrogen or C1-4 alkyl;
R2 is phenyl, naphthyl, benzofuranyl or benzothionyl, which is unsubstituted or substituted with 1-2 of C1-4 alkyl and/or halogen;
Q is (i) —CH2—O-Cyc1, (ii)-CH2-Cyc2 or (iii)-L-Cyc3;
Cyc1 is phenyl or pyridyl, which is unsubstituted or substituted with 1-2 of R4;
Cyc2 is indolyl which is unsubstituted or substituted with 1-2 of R4;
Cyc3 is phenyl substituted with 1-2 of R4;
L is —O— or —NH—;
R3a and R3b each independently is hydrogen or C1-4 alkyl or
R3a and R3b, taken together with the carbon atom to which they are attached, form tetrahydro-2H-pyran;
m is 2 or 3;
n is 0, 1 or 2;
R4 is C1-4 alkyl, C1-4 alkylthio, halogen or cyano, or when Cyc3 is phenyl substituted with two R4, two R4 taken together with phenyl may form
a salt thereof, a solvate thereof or a prodrug thereof.

10 more elements

Dependencies are inferred from the claim text.

Carboxylic acid compounds

Life of this patent

Carboxylic acid compounds

Life of this patent

Abstract

Claims12