Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof

A compound represented by formula (I) and its pharmaceutically or cosmetically acceptable salts

• wherein,
• R1 is hydrogen or selected from linear or branched (C1-C12) alkyl, (C2-C12) alkenyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl and wherein one or more heteroatoms when present are independently selected from O, N, or S and is optionally substituted, wherein the substituents are selected from a first group consisting of halogen, hydroxy, nitro, cyano, amino, oxo and oxime or from a second group consisting of linear or branched (C1-C8) alkyl, (C3-C7) cycloalkyl, alkylcycloalkyl, perhaloalkyl, perhalocycloalkyl, aryl, aralkyl, alkylaryl, alkylheteroaryl, aralkoxylalkyl, perhaloaryl, alkylheterocycloalkyl, heterocyclyloalkyl, perhaloheterocyclyloalkyl, heteroaryl, heteroaralkyl, alkylaryl, perhaloheteroaryl, acyl, alkoxyalkyl, thioalkyl and thioaryl, wherein the substitutents from said second group are optionally substituted by R10 and are optionally and independently bridged by —(CO)O—, —(CO)NH—, —NH—, —NR8—, —O—, —S—, —(SO)—, —(SO2), —(SO2)NH—, or —NH(CO)—;
• Y is selected from the group consisting of null, (C1-C12) alkyl-Z or (C2-C12) alkyl, wherein Z is selected from sulfur, oxygen or nitrogen;
• A and B are independently selected from NH, NR6, sulfur, oxygen or carbon to form a heteroaromatic ring system;
• R2, R3 and R4 are independently selected from a first group consisting of hydrogen, halogen, NO2, N═C(R8)(R9), —NR8R9, —OR8, perhaloalkyl, —(CO)NR8R9, —(CO)R8, —(CO)OR8, —O(CO)R8, —NH(CO)R8 or from a second group consisting of linear or branched (C1-C12)alkyl, (C2-C12)alkenyl, (C3-C7)cycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, wherein one or more members of said second group when present are optionally substituted by R10 and wherein one or more heteroatoms when present are independently selected from O, N, or S;
• R5 is null or selected from the group consisting of linear or branched (C1-C12)alkyl, (C2-C12)alkenyl, (C3-C7)cycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl;
• CH2(CO)R7, CH2(CO)NHR8, CH2(CO)NR8R9, and CH2(CO)OR7 which are optionally substituted by R10;
• R6 and R7 are independently selected from the group consisting of linear or branched (C1-C8) alkyl, (C3-C7)cycloalkyl, alkylcycloalkyl, perhaloalkyl, perhalocycloalkyl, aryl, aralkyl, alkylaryl, alkylheteroaryl, aralkoxylalkyl, perhaloaryl, alkylheterocycloalkyl, heterocyclyloalkyl, perhaloheterocyclyloalkyl, heteroaryl, heteroaralkyl, alkylaryl, perhaloheteroaryl, acyl, benzoyl, alkoxyalkyl, thioalkyl and thioaryl wherein members of said group are optionally substituted by R10;
• R8 and R9 are independently selected from the group consisting of linear or branched (C1-C12)alkyl, alkoxyaryl, alkoxyalkyl, alkoxycycloalkyl, alkoxyaryl, perhaloalkyl, (C2-C12)alkenyl, (C3-C7)cycloalkyl, perhalocycloalkyl, haloheterocycloalkyl, cyanoheterocycloalkyl, perhaloheterocycloalkyl, (C5-C7)cycloalkenyl, bicycloalkyl, bicycloalkenyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, perhaloaryl, perhaloheteroaryl wherein substituents of said group are optionally substituted by R10;
• R10 is selected from halogen, hydroxy, nitro, cyano, amino, oxo, perhaloalkyl(C1-C6), or oxime;
• X is selected from group comprising of a halide ion, acetate ion, perchlorate ion, sulfonate ion, oxalate ion, citrate ion, tosylate ion, maleate ion, mesylate ion, carbonate ion, sulfite ion, phosphoric hydrogen ion, phosphonate ion, phosphate ion, BF4− and PF6−
• provided when the groups/substituents are present on same or adjacent carbon or nitrogen atoms they together may optionally form a five or a six or a seven membered ring optionally containing one or more double bonds and optionally containing one or more heteroatoms selected from O, N, or S.