US 2007/0167486 A1 · Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same

Abstract

The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

Claims15

Dependent claims

A novel compound represented by the following general formula (I), the pharmaceutically acceptable salt or the isomer thereof:

wherein
X is a hydroxyl group, —NHOH, —NHOCH2Ph,
A is an hydrogen, A1 group or
A1 is a lower alkyl, lower alkenyl, lower alkynyl, lower allyl group having C1 to C5 carbon atoms, a heterocyclic group or aromatic aryl group selected from thiophenyl group, naphtyl group, pyrrolyl group, furyl group and biphenyl group, wherein the Y in A2 substituted is a lower alkyl group, lower alkoxy group, nitro, halogen, amine, acetamide, carbonamide or sulfonamide group, M is a lower alkyl group or phenyl group substituted with R′, of which R′ is a hydrogen, lower alkyl or lower alkoxy group, m and r is independently an integer of 1 to 5 respectively;
p is an integer of 0, 1 or 2;
n is an integer of 1 to 5;
dotted line (=) means single bond or double bond.

4 more elements

A novel compound represented by the following general formula (II), the pharmaceutically acceptable salt or the isomer thereof:

wherein
X is a hydroxyl group, —NHOH, —NHOCH2Ph,
Y is a lower alkyl group, lower alkoxy group, nitro, halogen, amine, acetamide, carbonamide or sulfonamide group;
M is a lower alkyl group or phenyl group substituted with R′, of which R′ is a hydrogen, lower alkyl or lower alkoxy group;
m and r is independently an integer of 1 to 5 respectively;
n is an integer of 1 to 5;
dotted line (=) means single bond or double bond.

4 more elements

A novel compound represented by the following general formula (IV), the pharmaceutically acceptable salt or the isomer thereof:

wherein
X is a hydroxyl group, —NHOH, —NHOCH2Ph,
Y is a lower alkyl group, lower alkoxy group, nitro, halogen, amine, acetamide, carbonamide or sulfonamide group;
M is a lower alkyl group or phenyl group substituted with R′, of which R′ is a hydrogen, lower alkyl or lower alkoxy group;
m and r is independently an integer of 1 to 5 respectively;
n is an integer of 1 to 5;
dotted line (=) means single bond or double bond.

4 more elements

Dependencies are inferred from the claim text.

Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same

Life of this patent

Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same

Life of this patent

Abstract

Claims15