6-Alkoxy-pyrido-pyrimidines

A method for treating rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohns disease, irritable bowel syndrome, inflammatory bowel disease, psoriasis, adult respiratory distress syndrome, asthma, or chronic obstructive pulmonary disease, comprising:

• administering to a patient in need of such treatment, an effective amount of a compound of Formula I
• or a pharmaceutically acceptable salt thereof,
• wherein:
• Z is CH:
• X1 is O, NR4 (where R4 is hydrogen or alkyl). S or C═O:
• R1 is alkyl, cycloalkyl, cycloalkylalkyl or —CH2-alkenyl:
• R2 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, alkylene-C(O)—R21 (where R21 is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylamino, acyl, or NR22—Y—R23 (where Y is —C(O), —C(O)O—, —C(O)NR24, S(O)2 or S(O)2NR25;
• R22, R24 and R25 are independently hydrogen or alkyl;
• and R23 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally-substituted phenyl);
• and
• R3 is alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, cyanoalkyl, heterocyclyl, heterocyclylalkyl, or -heterocycloamino-SO2—R12 (where R12 is haloalkyl, aryl, aryalkyl, heteroaryl or heteroaralkyl).