Novel Processes for the Production of Useful Intermediates

A process for the production of compounds of formula (I)

• and pharmaceutically acceptable salts and esters thereof, comprising
• a) reacting a compound of formula (II),
• with a compound of formula (III),
• and
• b) further reacting in the presence of alkali- or earth alkali metal hydroxides to give the compounds of formula (I),
• wherein
• R and R1 are independently, alkyl or benzyl, which benzyl is optionally substituted by one, two or three substituents including —O-alkyl;
• alkyl or halogen;
• with the proviso that:
• if R is alkyl, R1 in formula (I) may also be hydrogen or silyl, and R1 in formula (II) may also be silyl;
• R2 is hydrogen or halogen;
• X is
• R3 and R4 are hydrogen, phenyl, alkyl or
• —C(CH3)2-phenyl;
• R5 is phenyl, benzyl or alkyl;
• R6 is hydrogen, alkyl or phenyl;
• and
• R7 is hydrogen, methyl or phenyl;
• or alternatively
• R5 and R6, together with the carbon atoms to which they are attached form an indan moiety and R7 is hydrogen;
• R11 and R12 are independently alkyl, cycloalkyl, benzyl or phenyl;
• and
• R13 is phenyl or alkyl.