Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto

A compound of Formula (Ia):

• or a pharmaceutically acceptable salt, solvate or hydrate thereof;
• wherein:
• X is N or CR8 wherein R8 is H or halogen;
• Y is NH or O;
• Z is CH or N;
• R1 is carbo-C1-6-alkoxy, oxadiazolyl or pyrimidinyl wherein said carbo-C1-6-alkoxy, oxadiazolyl and pyrimidinyl are each optionally substituted with 1 or 2 substituents selected independently from the group consisting of C1-4 alkyl, C1-4 alkoxy and C3-5 cycloalkyl;
• R2 is H or C1-4 alkyl;
• R3 is C1-4 alkoxy, O—C2-4-alkynyl or hydroxyl;
• R4 is selected from the group consisting of H, C1-4 alkoxy, C1-4 alkyl, C2-4 alkynyl and halogen;
• R5 is selected from the group consisting of C1-4 acylsulfonamide, C1-4 alkoxy, C1-4 alkyl, C1-4 alkylamino, C1-4 alkylsulfonyl, C1-4 alkylthio, cyano, heterocyclyl, di-C1-4-dialkylamino and sulfonamide, wherein said C1-4 alkoxy, C1-4 alkyl, C1-4 alkylamino, C1-4 alkylsulfonyl, C1-4 alkylthio, di-C1-4-dialkylamino and heterocyclyl are each optionally substituted with 1 or 2 substituents selected independently from the group consisting of C2-4 alkynyl, C1-4 alkoxy, C1-4 alkylcarboxamide, C1-4 alkylsulfonyl, C3-5 cycloalkyl, C3-5 cycloalkyloxy, di-C1-4-alkylcarboxamide, hydroxyl and phosphonooxy, wherein said C1-4 alkylcarboxamide is optionally substituted with hydroxyl;
• or
• R5 is a group of Formula (A):
• wherein “m”, “n” and “q” are each independently 0, 1, 2 or 3;
• “r” is 0, 1 or 2;
• and “t” is 0 or 1;
• R6 is H or halogen;
• and
• R7 is H or C1-4 alkyl.