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US 2007/0167467 A1Published application
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
AssigneeSmithKline Beecham Corporation
InventorsJerry Adams, Jeffrey Boehm, John Taggart, Ralph Hall
Life of this patent
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Abstract
Novel substituted pyrimido[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
Claims24
1-70. (canceled)
A compound of the formula:
- wherein
- X1 is a C1-10 alkyl, aryl or heteroaryl moiety;
- R1 is an optionally substituted aryl or an optionally substituted heteroaryl ring;
- R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7cycloalkylC1-10alkyl, aryl, arylC1-10alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety;
- and wherein each of these moieties are optionally substituted;
- and
- Y is a bond.
4 more elements
The compound which is
- wherein
- X1 is a C1-10 alkyl, aryl or heteroaryl moiety;
- R1 is an aryl or a heteroaryl ring, which ring is optionally substituted;
- R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7cycloalkylC1-10alkyl, aryl, arylC1-10alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety;
- and wherein each of these moieties are optionally substituted;
- and
- Y is a bond.
4 more elements
Dependencies are inferred from the claim text.