Tetrahydro-naphthalene and urea derivatives

A compound of the formula (I), their tautomeric and stereoisomeric form, and salts thereof:

• wherein
• A represents the formula
• wherein
• ∩ represents the connection position to the molecule,
• Q1a and Q4a independently represent direct bond or methylene,
• Q2a represents CHR2a,
• Q3a represents CHR3a,
• wherein
• R2a represents hydrogen, hydroxy, C1-6 alkoxy or C1-6 alkaoyloxy, and
• R3a represents hydrogen, hydroxy, C1-6 alkoxy, or C1-6 alkanoyloxy,
• with the proviso that Q1a and Q4a can not be direct bond at the same time and R2a and R3a can not be hydrogen at the same time,
• and
• E represents the formula
• wherein
• # represents the connection position to the molecule,
• Q1b, Q2b, Q4b and Q5b independently represent C(R11b)(R12b),
• wherein
• R11b and R12b independently represent hydrogen, phenyl, benzyl, or C1-6 alkyl optionally substituted by hydroxy, carboxy, phenyl, benzyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkylamino, or di(C1-6 alkyl)amino;
• Q3b represents C—R13b,
• wherein
• R13b represents hydrogen, phenyl, benzyl, or C1-6alkyl optionally substituted by hydroxy, carboxy, phenyl, benzyl, C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkylamino, or di(C1-6alkyl)amino;
• R1b represents C1-6alkyl substituted by aryl or heteroaryl,
• wherein
• said aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of halogen, nitro, hydroxy, C1-6 alkylamino, di(C1-6alkyl)amino, C3-8 cycloalkylamino, C1-6 alkoxycarbonyl, phenyl, benzyl, heterocycle, sulfonamide, C1-6 alkanoyl, C1-6 alkanoylamino, carbamoyl, C1-6alkylcarbamoyl, cyano, C1-6alkyl optionally substituted by cyano, C1-6 alkoxycarbonyl or mono-, di-, or tri-halogen, C1-6 alkoxy optionally substituted by mono-, di-, or tri- halogen, phenoxy optionally substituted by halogen or C1-6 alkyl, or C1-6 alkylthio optionally substituted by mono-, di-, or tri- halogen, C3-8 cycloalkyl, and heterocycle;
• or
• aryl or heteroaryl,
• wherein
• said aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of halogen, nitro, hydroxy, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, C1-6 alkoxycarbonyl, phenyl, benzyl, heterocycle, sulfonamide, C1-6 alkanoyl, C1-6 alkanoylamino, carbamoyl, C1-6 alkylcarbamoyl, cyano, C1-6 alkyl optionally substituted by cyano, C1-6 alkoxycarbonyl or mono-, di-, or tri-halogen, C1-6 alkoxy optionally substituted by mono-, di-, or tri- halogen, phenoxy optionally substituted by halogen or C1-6 alkyl, or C1-6 alkylthio optionally substituted by mono-, di-, or tri- halogen, C3-8 cycloalkyl, and heterocycle;
• na represents 1 or 2;
• ma represents 0, 1, 2, or 3;
• —Xa— represents bond, —O— or —N(R1a)— (wherein R1a is hydrogen or C1-6 alkyl);
• and
• Ra represents aryl or heteroaryl
• Wherein said aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, C1-6 alkoxycarbonyl, phenyl (which phenyl is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl), benzyl (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl), sulfonamide, C1-6 alkanoyl, C1-6 alkanoylamino, carbamoyl, C1-6 alkylcarbamoyl, cyano, C1-6 alkyl (which alkyl is optionally substituted by cyano, nitro, hydroxy, carboxy, amino, C1-6 alkoxycarbonyl or mono-, di-, or tri-halogen), C1-6 alkoxy (which alkoxy is optionally substituted by mono-, di-, or tri- halogen), phenoxy (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl or C1-6 alkyl), C1-6 alkylthio (which alkylthio is optionally substituted by mono-, di-, or tri- halogen), C3-8 cycloalkyl, and heterocycle.