Mercaptoimidazoles as ccr2 receptor antagonists

A compound of formula

• a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein
• R1 represents hydrogen, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxyC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl or heteroaryl;
• each R2 independently represents halo, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, nitro, aryl or aryloxy;
• R3 represents cyano, C(═O)—O—R5, C(═O)—NR6aR6b or C(═O)—R7;
• or a cyclic ring system selected from
• R4 represents hydrogen or C1-6alkyl;
• R5 represents hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C2-6alkenyl, C2-6alkynyl, polyhaloC1-6alkyl, C1-6alkyloxyC1-6alkyl optionally substituted with C1-6alkyloxy, aminoC1-6alkyl, mono- or di(C1-4alkyl)aminoC1-6alkyl, aminocarbonylC1-6alkyl, mono- or di(C1-4alkyl)aminocarbonylC1-6alkyl, aryl or arylC1-6alkyl;
• R6a and R6b each independently represent hydrogen, C1-6alkyl, amino, mono- or di(C1-4alkyl)amino, arylNH—, aminoC1-16alkyl, mono- or di(C1-4alkyl)amino-C1-6alkyl, C1-6alkylcarbonylamino, aminocarbonylamino, C1-6alkyloxy, carbonylamino or hydroxyC1-6alkyl;
• or
• R6a and R6b taken together with the nitrogen to which they are attached form pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl or piperazinyl substituted with C1-6alkyl;
• R7 represents hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C2-6alkenyl, C2-6alkynyl, polyhaloC1-6alkyl, C1-6alkyloxyC1-6alkyl, aminoC1-6alkyl, mono- or di(C1-4alkyl)aminoC1-6alkyl, aminocarbonylC1-6alkyl, mono- or di(C1-4alkyl)aminocarbonylC1-6alkyl, aryl or heteroaryl;
• each R8 independently represents hydrogen, halo, C1-6alkyl, C1-6alkyloxy, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, mono- or di(C1-4alkyl)aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, hydroxyC1-6alkylamino, aryl, aryloxy, piperidinyl, piperidinylamino, morpholinyl, piperazinyl or nitro;
• each R9 independently represents hydrogen, halo or C1-6alkyl;
• R10 represents hydrogen, C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, heteroarylcarbonyl, —C(═O)—NH—R5, —C(═S)—NH—R5 or —S(═O)2—R5;
• n is 1, 2, 3, 4 or 5;
• aryl represents phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, mono- or di(C1-4alkyl)aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, phenyloxy or nitro;
• heteroaryl represents pyrrolidinyl, tetrahydrofuranyl, imidazolidinyl, pyrazolidinyl, pyrrolinyl, imidazolinyl, pyrazolinyl, furanyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, each of said heterocycles optionally being substituted with one or two substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, mono- or di(C1-4alkyl)aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, nitro or arylC1-6alkyl.