Derivatives of sulphonamides, their preparation and use as medicaments

A process for preparing a derivative of sulphonamide with the general formula (I)

• wherein
• A represents a substituent selected from among:
• A heteroaromatic ring of 5 or 6 members containing 1 or 2 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms, by a C1-C4 alkyl radical or by a phenyl radical or a heteroaryl radical with 5 or 6 members containing 1 or 2 atoms of oxygen, nitrogen or sulphur;
• A bicyclic heteroaromatic ring containing 1 to 3 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms or by a C1-C4 alkyl radical;
• A group selected from among:
• R1 represents hydrogen, a C1-C4 alkyl radical or a benzyl radical;
• n represents 0, 1, 2, 3 or 4;
• R2 represents —NR4R5 or a group with formula:
• wherein the dotted line represents an optional chemical bond;
• and
• R3, R4, and R5 independently represent hydrogen or a C1-C4 alkyl;
• X, Y and Z independently represent hydrogen, fluorine, chlorine, bromine, a C1-C4 alkyl, a C1-C4 alkoxy, a C1-C4 alkylthio, trifluoromethyl, cyano, nitro and —NR4R5;
• W represents a bond between the two rings, CH2, O, S and NR4;
• m represents 0, 1, 2, 3 or 4;
• with the condition that when m=0, A is a substituted phenyl;
• or one of its physiologically acceptable salts;
• said process comprising the steps of:
• reacting a compound with the general formula (II), or one of its suitably protected derivatives,
• wherein A is as indicated previously in the general formula (I), and X is a suitable leaving group including an halogen atom, particularly chlorine;
• with a 5-aminoindole with the general formula (III), or one of its suitably protected derivatives;
• wherein n, R1, R2 and R3 are as indicated above in the general formula (I);
• in order to obtain the corresponding sulphonamide, and optionally it is possible to remove eventually the protective groups from it.