Treatment for embolic stroke
AssigneeThe Regents of the University of California
InventorsPaul Lapchak, Dalia Araujo, Justin Zivin
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Abstract
Provided herein are methods and compositions for treating stroke that include contacting a subject suffering from a stroke with (1) an antioxidant; (2) an antioxidant and one or more of (i) a thrombolytic agent, (ii) an NMDA receptor antagonist and (iii) a spin trap agent; or (3) a thrombolytic agent in combination with one or more of (i) an NMDA receptor antagonist and (ii) a spin trap agent.
Claims27
A method of treating stroke comprising:
- contacting a subject suffering from a stroke with:
- a) an NMDA receptor antagonist;
- b) an agent that increases reperfusion of an affected area in an amount sufficient to allow for the penetration of a spin trap agent;
- and
- c) a spin trap agent in an amount sufficient to reduce cell and/or tissue damage.
A method of treating stroke comprising contacting a subject suffering from a stroke with an agent that increases reperfusion of an affected area;
- and contacting the subject with an NMDA receptor antagonist in an amount sufficient to reduce cell and/or tissue damage.
A formulation comprising a thrombolytic agent and (i) an NMDA receptor antagonist, or (ii) a combination of an NMDA receptor antagonist and a spin trap agent.
Dependencies are inferred from the claim text.