Novel heterocycles

A compound of the general formula (I),

• derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein A represents substituted or unsubstituted aryl group;
• wherein B represents substituted or unsubstituted groups selected from aryl or pyridyl;
• and X represents carbon or nitrogen atom;
• when B is pyridyl then R is selected from azido, halogens comprising fluorine, chlorine, bromine, iodine, substituted or unsubstituted groups selected from alkoxy groups comprising methoxy, ethoxy, n-propoxy and isopropoxy, aryl groups comprising phenyl and naphthyl, acyl groups comprising acetyl and benzoyl, substituted or unsubstituted linear or branched (C1-C6) alkyl groups, comprising methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, n-pentyl, isopentyl and hexyl, cycloalkyl groups comprising cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, haloalkyl groups comprising chloromethyl, chloroethyl, trifluoromethyl, trifluoroethyl, dichloromethyl and dichloroethyl, amino, hydrazine groups comprising hydrazine and methylhydrazine, monoalkylamino groups comprising —NHCH3, —NHC2H5, —NHC3H7 and —NHC6H13, dialkylamino groups comprising —N(CH3)2, —NCH3(C2H5) and —N(C2H5)2, acylamino groups comprising —NHC(═O)CH3, —NHC(═O)C2H5, —NHC(═O)C3H7 and —NHC(═O)C6H13, alkylsufonyl groups comprising methylsulfonyl, ethylsulfonyl, n-propylsulfonyl and iso-propylsulfonyl, alkylsulfinyl groups comprising methylsulfinyl, ethylsulfinyl, n-propylsulfinyl and iso-propylsulfinyl, arylsulfonyl, arylsulfinyl, alkoxycarbonyl groups comprising methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl and isopropoxycarbonyl, aryloxycarbonyl groups comprising phenoxycarbonyl and napthoxycarbonyl, sulfamoyl;
• R1 represents hydrogen, hydroxy, nitro, formyl, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl groups comprising phenyl, naphthyl;
• aryloxy groups comprising phenoxy and napthoxy, acyloxy groups comprising MeCOO—, EtCOO— and PhCOO—, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxy, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• R2 represents hydrogen, hydroxy, nitro, formyl, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH, —SO2Cl, carboxylic acid and its derivatives;
• R3 represents hydrogen, hydroxy, nitro, formyl, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• R4 represents hydrogen, hydroxy, nitro, formyl, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• and X represents nitrogen;
• when B is aryl or pyridyl then R represents substituted or unsubstituted groups selected from aryl, heteroaryl, the heteroaryl groups are selected from pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, thiadiazolyl, tetrazolyl, pyrimidinyl, pyrazine, benzofuranyl, benzimidazolyl and benzothiazolyl;
• aryloxy, —OSO2R′ (wherein R′ is selected from substituted or unsubstituted:
• alkyl, aryl, alkyldialkylamino, haloalkyl, heterocyclyl and heteroaryl) and heterocyclyl groups comprising morpholine, piperazine, piperidine, pyrrolidine and thiazolidine;
• the heterocyclyl group is optionally substituted with substitutents independently selected from substituted or unsubstituted heteroaryl, alkylaryl (—CH2-Aryl), alkylheteroaryl (—CH2-Heteroaryl), substituted heteroarylcarbonyl (—CO-Heteroaryl), cyanoalkyl, alkylsulfonyl, haloalkylsulfonyl, formyl and another substituted or unsubstituted heterocyclyl group;
• the attachment of the heterocyclyl group to the pyrimidine ring is through carbon or nitrogen;
• R1 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups are selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2—SO2Cl, carboxylic acid and its derivatives;
• R2 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2,d —SO2Cl, carboxylic acid and its derivatives;
• R3 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• R4 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups selected from alkyl, haloalkyl, alkoxy, aryl, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• and X represents carbon or nitrogen atom;
• when A and B are both aryl then R is selected from azido, halogens, substituted or unsubstituted groups selected from alkyl, alkoxy, acyl, cycloalkyl, haloalkyl, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsufonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, alkoxycarbonyl, aryloxycarbonyl, alkoxyalkyl and sulfamoyl;
• R1 represents hydrogen, substituted sulfamoyl, substituted or unsubstituted —SO2NHNH2 and —SO2Cl;
• R3 represents hydrogen, substituted sulfamoyl, substituted or unsubstituted —SO2NHNH2 and —SO2Cl;
• provided that any one of R1 or R3 is always substituted sulfamoyl, or substituted or unsubstituted —SO2NHNH2, or —SO2Cl;
• R2 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups selected from alkyl, aryl, haloalkyl, alkoxy, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsulfonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• R4 represents hydrogen, hydroxy, nitro, azido, halogens, substituted or unsubstituted groups selected from alkyl, aryl, haloalkyl, alkoxy, aryloxy, acyloxy, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsulfonyl, alkylsulfinyl, alkylthio, alkoxycarbonyl, alkoxyalkyl, sulfamoyl, —SO2NHNH2, —SO2Cl, carboxylic acid and its derivatives;
• when the groups R, R1, R2, R3, R4 and R′ are substituted by one or more substituents these substituents are selected from halogens, hydroxy, nitro, cyano, ureas, azido, amino, imino-1-phenyl butanone, amide, thioamide, hydrazine, alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, aryloxy, acyl groups comprising acetyl and benzoyl, haloacyl, acyloxyacyl, heterocyclyl, aryl, heteroaryl, monoalkylamino, dialkylamino, acylamino, alkoxycarbonyl groups comprising methoxycarbonyl and ethoxycarbonyl, aryloxycarbonyl, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, thioalkyl, thioaryl, sulfamoyl, alkoxyalkyl groups, carboxylic acids and its derivatives comprising hydroxamic acid, hydroxamates, esters, amides and acid halides. These substituents are further optionally substituted with substituents selected from hydroxy, alkoxy, halogens, haloalkyl, alkyl and aryl which in turn is optionally further substituted by groups comprising halogens and alkyl.