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US 2007/0167412 A1Published application
Halocombstatins and methods of synthesis thereof
AssigneeArizona Board of Regents
InventorsGeorge Pettit, Mathew Minardi, Heidi Rosenberg
Life of this patent
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Abstract
The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
Claims17
A compound having a structure as follows:
- wherein X is F, Cl, Br or I.
A compound having a structure as follows:
- wherein X is F, Cl, Br or L and R is a metal cation such as Na, Li, K, Cs, Rb, Ca, Mg or is morpholine, pipenidine, glycine-OCH3, tryptophan-OCH3 or NH(CH2OH)3.
A compound having a stucture as follows:
- wherein X is F, Cl, Br or I, and Z is a metal cation such as Na, Li, K, Cs, Rb, Ca, Mg or is morpholine, piperidine, glycine-OCH3, typtophan-OCH3 or NH(CH2OH)3.
Dependencies are inferred from the claim text.