Methods and compositions for joint lubrication
AssigneeSolazyme, Inc.
InventorsHarrison Dillon, Aravind Somanchi, Anwar Zaman
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Abstract
The invention provides novel polysaccharide molecules with high levels of viscosity. These compositions can be used for lubricating the joints of mammals to treat diseases of the joint such as osteoarthritis. Also provided are methods of using polysaccharides for applications such as lubricating joints. Also provided are methods of generating polysaccharides for increasing advantageous rheological properties, such as increased viscosity.
Claims21
A polysaccharide with novel viscosity produced from a cell of the genus Porphyridium, comprising xylose, glucose, and galactose wherein the molar amount of glucose in the polysaccharide is at least 65% of the molar amount of galactose.
5-17. (canceled)
A method of lubricating the joint of a mammal, comprising injecting a polysaccharide produced by microalgae into a cavity containing synovial fluid of the mammal.
The method of claim 19, wherein the polysaccharide is produced by a microalgae listed in Table 1.
21-36. (canceled)
A method of mammalian joint lubrication comprising injecting an exopolysaccharide from microalgae into a mammalian joint, wherein the exopolysaccharide:
- a. is sterile;
- and
- b. is substantially free of protein.
Dependencies are inferred from the claim text.