Loading patent…
AssigneeNational Taiwan University
InventorsMin-Liang Kuo, Cheng-Chi Chang
Estimating the term…
Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue growth factor (CTGF, also known as CCN2) to determine the status of tumor invasion. Another aspect of the invention relates to a method and a composition comprising a tumor suppressor, which maintains or increases an expression level of CTGF to suppress the invasion ability of tumor cells effectively. In another aspect of the invention relates to methods for obtaining a metastasis suppressor by evaluating the expression levels of CTGF after contacting suppressor candidates with a tumor cell line system.
A pharmaceutical composition for treating/suppressing metastatic tumors, comprising an effective amount of suppressor to maintain or increase the expression CTGF levels in tumor cells, and a nucleotide sequence encoding the CTGF is SEQ ID NO:
A method for treating/suppressing metastatic tumors, comprising the steps of administrating a pharmaceutical composition to an individual suffering from a cancer, wherein the composition comprises an effective amount of tumor suppressor to maintain or increase the expression levels of CTGF, and a nucleotide encoding the CTGF is SEQ ID NO:
A method for obtaining a metastasis suppressor that elevates expression levels of CTGF, comprising the steps of:
Dependencies are inferred from the claim text.