Nucleotide sequences promoting the trans-membrane transport of nucleic acids
AssigneeUniversitätsklinikum Schleswig-Holstein Campus Lübeck
InventorsGeorg Sczakiel, Anne Hopert, Winfried Wunsche, Marita Overhoff
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel system for the trans-membrane transport including the cellular uptake/delivery of nucleic acids, substances that contain a nucleic acid component, recombinant genetic material or substances that can be attached to a nucleic acid, in biological systems. In particular, the present invention relates to a nucleic acid comprising a first nucleotide sequence having a specific signal sequence, wherein said signal sequence increases or causes the uptake of the nucleic acid into a cell, and a pharmaceutical composition containing said nucleic acid.
Claims12
A nucleic acid comprising a first nucleotide sequence having at least one signal sequence selected from the group consisting of unit 5′-(CCGTGT)n-3′, unit 5′-(TCGTGT)n-3′, unit 5′-TCGTG)-3, unit 5′-(CGTG)n-3′, unit 5′-(TCGT)n-3′, unit 5′-(TCG)n-3′ and unit 5′-(CGT)n-3′ and mixtures of said units, wherein n is an integer ranging from 1 to 10, said signal sequence causing a trans-membrane transport of the nucleic acid in a biological system.
The nucleic acid according to any preceding claim, wherein the biological system is a mammalian cell.
Dependencies are inferred from the claim text.