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US 2007/0167385 A1Published application
Antisense oligonucleotides (odn) against smad7 and uses in medical field thereof
AssigneeGiuliani Internaitonal Limited
InventorGiovanni Monteleone
Life of this patent
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Abstract
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
Claims16
Antisense oligonucleotides phosphorothioate against Smad7 up to 21 nucleotides in length which comprise a portion of at least 10 nucleotides of the following sequence (SEQ ID No 2):
- 5′-GTXYCCCCTTCTCCCXYCAG-3′ wherein X is a nucleotide comprising a nitrogenous base selected from the group consisting of cytosine, 5-methylcytosine and 2′-0-methylcytosine and wherein Y is a nucleotide comprising a nitrogenous base selected from the group consisting of guanine, 5-methylguanine e 2′-0-methylguanine, provided that at least one of the nucleotides X or Y comprises a methylated nitrogenous base;
- or the complementary sequence thereto.
Dependencies are inferred from the claim text.