Macrolides with antiinflammatory activity

1) A compound of formula

• wherein
• X is a —C(═O)—, —C(═O)—O—, —C(═O)—N—, —SO2— or —SO2—N group;
• R is a hydrogen atom or methyl;
• R1 is a hydrogen atom or a (C1-C3)-alkyl group;
• R2 is a hydrogen atom, a (C1-C4)-alkoxy-(C1-C4)-alkyl group, a (C5-C7)-cycloalkyl group, a phenyl or a five- or six-membered heteroaryl having from one to three heteroatoms selected among nitrogen, oxygen and sulphur, a phenyl-(C1-C4)-alkyl or heteroaryl-(C1-C4)-alkyl group optionally substituted by 1 to 3 substituents selected among a (C1-C4)-alkyl group, a (C1-C4)-alkoxy group and halogen, or a chain of formula
• —(CH2)r—Y—(CH2)m-A
• wherein
• A is a phenyl or a five- or six-membered heteroaryl having from one to three heteroatoms selected among nitrogen, oxygen and sulphur, both ones optionally substituted by 1 to 3 substituents selected among a (C1-C4)-alkyl group, a (C1-C4)-alkoxy group or halogen;
• Y represents O, S or NR6 wherein R6 is a hydrogen atom, a linear or branched (C1-C3) alkyl, a (C1-C3)-alkoxycarbonyl group or a benzyloxycarbonyl group;
• r is an integer comprised between 1 and 3;
• m is an integer comprised between 0 and 3;
• R3 is a hydroxy group or R3 taken together with R4 forms a (═O) group or a ═N—O—R5 group wherein R5 is a hydrogen atom, a (C1-C4)-alkyl group, a benzyl or a —X—R2 group wherein X and R2 have the corresponding meanings defined above;
• R4 is a hydrogen atom or R4 taken together with R3 forms a (═O) group or a ═N—O—R5 group wherein R5 has the meanings defined above;
• and furthermore R2 is a (C1-C10)-alkyl group or a (C4-C10)-alkyl group when, at the same time, X is a —C(═O)— group, R1 is a (C1-C3)-alkyl group and R3 is a hydroxy group or R3 taken together with R4 forms a ═N—O—R5 group wherein R5 is different from —X—R2;
• and pharmaceutically acceptable salts thereof.