Inhibitors of glycinamide ribonucleotide transformylase

A compound represented by the following structure:

• wherein:
• R1 is a radical selected from the group consisting of —C(O)H, —CH2OH, —CH═NNMe2, —C(O)CF3, and —CH(OH)CF3;
• R2 is a radical selected from the group consisting of —OH, —OtBu, glutamyl, and oligoglutamyl;
• R3 is a radical selected from the group consisting of —OH, —OtBu, glutamyl, and oligoglutamyl;
• each glutamyl being independently represented by the formula:
• —NHCH(C(O)R4)(CH2)2C(O)R5 wherein R4 and R5 are each radicals independently selected from the group consisting of —OH and —OtBu;
• each oligoglutamyl having at least one terminal glutamyl and between one and four non-terminal glutamyl residues;
• each terminal glutamyl being independently represented by the formula —NHCH(C(O)R4)(CH2)2C(O)R5 wherein R4 and R5 are each radicals independently selected from the group consisting of —OH and —OtBu;
• each non-terminal glutamyl being independently represented by the formula —NHCH(C(O)R6)(CH2)2C(O)R7 wherein R6 and R7 are each radicals independently selected from the group consisting of —OH, —OtBu, terminal glutamyl, and non-terminal glutamyl;
• with a proviso that at least one of R6 and R7 is either terminal glutamyl or non-terminal glutamyl.