Specific antagonists for glucose-dependent insulinotropic polypeptide (GIP)
OwnerM. Wolfe, Chi-Chuan Tseng +1inventors
InventorsM. Wolfe, Chi-Chuan Tseng, Linda Neville
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OwnerM. Wolfe, Chi-Chuan Tseng +1inventors
InventorsM. Wolfe, Chi-Chuan Tseng, Linda Neville
Estimating the term…
In one embodiment, this invention provides an antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7-30 of the sequence of GIP. In another embodiment, this invention provides a method of preventing and treating obesity and non-insulin dependent diabetes mellitus (Type II) in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP). In yet another embodiment, this invention provides a method of improving glucose tolerance in a mammal comprising administering to the mammal an antagonist of glucose-dependent insulinotropic polypeptide (GIP).
1) An antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7-30 of the sequence of GIP.
2) A method of treating non-insulin dependent diabetes mellitus in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP).
3) A method of improving glucose tolerance in a non-insulin dependent diabetes mellitus patent comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP).
4) A method of preventing, inhibiting or reducing obesity in an animal comprising administering to the animal an antagonist of glucose-dependent insulinotropic polypeptide (GIP) to inhibit, block or reduce glucose absorption from the intestine of the animal.
8) An antagonist of glucose-dependent insulinotropic polypeptide (GIP).
11) A pharmaceutical composition for preventing, inhibiting or reducing obesity in an animal comprising:
17) A method of developing a nonpeptide GIP antagonist comprising:
Dependencies are inferred from the claim text.