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US 2007/0167372 A1Published application
Ocular tear growth factor-like protein
AssigneeUniversity of Virginia Patent Foundation
InventorsGordon Laurie, Sandhya Sanghi, Kumar Rajesh, Angela Lumsden
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Abstract
The present invention relates to a novel lacrimal gland protein (designated lacritin) and the nucleic acid sequences encoding that protein. Lacritin has activity as a growth factor on both human corneal epithelial cells and on the lacrimal acinar cells that produce it. Accordingly, one embodiment of the present invention is directed to the use of lacritin to treat Dry Eye and other disorders requiring the wetting of the eye.
Claims2
1-21. (canceled)
A method for detecting a lacritin receptor, said method comprising
- providing a cell that has been transfected with nucleic acid sequences that encode for potential cell receptors;
- contacting said transfected cells with lacritin;
- detecting cells that display lacritin-dependent calcium signaling;
- isolating nucleic acid sequences from the detected cells;
- and
- identifying a nucleic acid sequence that confers lacritin-dependent calcium signaling on cells transfected with that nucleic acid sequence.
3 more elements
Dependencies are inferred from the claim text.