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US 2007/0167352 A1Published application
Methods and compositions for oxygen transport comprising a method for making a high oxygen affinity modified hemoglobin
AssigneeSangart, Inc.
InventorsRobert Winslow, Kim Vandegriff
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Abstract
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
Claims2
to 13. (canceled)
A method of making a blood substitute product comprising the steps of:
- a) preparing an oxygenated hemoglobin solution;
- b) thiolating the oxygenated hemoglobin to form thiolated oxygenated hemoglobin;
- c) reacting the thiolated oxygenated hemoglobin with maleimidyl polyethylene glycol to form polyethylene glycol modified hemoglobin;
- wherein the polyethylene glycol modified hemoglobin has a P50 less than two thirds that of native stroma-free hemoglobin from the same animal source when measured under the same conditions.
1 more element
Dependencies are inferred from the claim text.