West nile vaccine
AssigneeWyeth
InventorHsien-Jue Chu
Life of this patent
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Abstract
The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
Claims14
1-9. (canceled)
A method for the prevention or amelioration of West Nile encephalitis in equidae which comprises administering to said equidae a vaccine composition which comprises an effective immunizing amount of DNA derived from a West Nile virus;
- an immunogenically stimulating amount of a metabolizable oil;
- and a pharmacologically acceptable carrier.
(canceled)
17-19. (canceled)
The method according to claim 19 wherein the metabolizable oil is SP oil and is present in an amount of about 5% vol/vol.
21-41. (canceled)
A method for the prevention or amelioration of West Nile encephalitis in equidae, said method comprising administering to said equidae a vaccine composition comprising West Nile virus plasmid DNA in an amount of about 50 to 3,000 micrograms per dose.
Dependencies are inferred from the claim text.