Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
OwnerHaixiang Lin, Lie Liinventors
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Abstract
The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with other immunogenic compositions such as an antigen (e.g., as in a vaccine). The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response to an antigenic compound.
Claims17
An immunogenic composition comprising a PIKA adjuvant and an antigen, wherein the immunogenic composition is formulated for sustained release.
An immunogenic composition comprising PIKA adjuvant and a viral antigen wherein the antigen is an antigen of adeniviridae, arenaviridae, astroviridae, bunyaviridae, cliciviridae, flaviviridae, hepatitis delta virus, hepeviridae, mononegavirales, nidovirales, piconaviridae, orthomyxoviridae, papillomaviridae, parvoviridae, polyomaviridae, poxyiridae, reoviridae, retroviridae or togaviridae.
An immunogenic composition comprising PIKA adjuvant and a bacterial antigen wherein the antigen is an antigen of actinobacteria, chlamydiae, firmicutes, proteobacteria or spirochaetes.
An immunogenic composition comprising PIKA adjuvant and a fungal antigen wherein the antigen is an antigen of ascomycotaor or basidiomycota.
An immunogenic composition comprising PIKA adjuvant and a parasitic antigen wherein the antigen is an antigen of phylum sarcomastigophora, phylum apiicomplexa, phylum ciliophora, phylum plathyhelminthes, phylum nematoda or phylum arthropoda.
An immunogenic composition comprising PIKA adjuvant and a cancer antigen wherein the antigen is a cancer antigen of bone, brain, breast, digestive/gastrointestinal, endocrine, eye, genitourinary, germ cell, gynecologic, head and neck, hematological/blood, lung, musculoskeletal, neurologic, respiratory/thoracic or skin cancer.
An immunogenic composition comprising PIKA adjuvant and a combination of two or more antigens wherein the antigens are antigens of adeniviridae, arenaviridae, astroviridae, bunyaviridae, cliciviridae, flaviviridae, hepatitis delta virus, hepeviridae, mononegavirales, nidovirales, piconaviridae, orthomyxoviridae, papillomaviridae, parvoviridae, polyomaviridae, poxyiridae, reoviridae, retroviridae, togaviridae, actinobacteria, chlamydiae, firmicutes, proteobacteria or spirochaetes, ascomycotaor basidiomycota, phylum sarcomastigophora, phylum apiicomplexa, phylum ciliophora, phylum plathyhelminthes, phylum nematoda or phylum arthropoda.
Dependencies are inferred from the claim text.