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US 2007/0166796 A1Published application
Il-21 antagonists
AssigneeZymoGenetics, Inc.
InventorsScott Presnell, James West, Julia Novak
Life of this patent
Estimating the term…
Abstract
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC50 that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor.
Claims3
An expression vector, comprising:
- an isolated polynucleotide molecule encoding an IL-21 antagonist polypeptide comprising an amino acid sequence as shown as in SEQ ID NO:
- 4 or SEQ ID NO:
- 6.,
- a transcription promoter, and
- a transcription terminator, wherein the promoter is operably linked with the nucleic acid molecule, and wherein the nucleic acid molecule is operably linked with the transcription terminator.
2 more elements
Dependencies are inferred from the claim text.