Cytokine zalpha11 ligand fusion proteins

A fusion protein comprising at least four polypeptides, wherein the order of polypeptides from N-terminus to C-terminus are:

• a first polypeptide that comprises a sequence of amino acid residues from 41 to 56 of SEQ ID NO:
• 2;
• a first spacer of 6-27 amino acid residues;
• a second polypeptide that comprises a sequence of amino acid residues selected from the group consisting of:
• (a) IL-2 helix B residues 53-75 of SEQ ID NO:
• 111;
• (b) IL-4 helix B residues 65-83 of SEQ ID NO:
• 112;
• (c) IL-15 helix B residues 84-101 of SEQ ID NO:
• 113;
• (d) GMCSF helix B residues 72-81 of SEQ ID NO:
• 114;
• and
• (e) amino acid residues 69-84 of SEQ ID NO:
• 2;
• a second spacer of 5-11 amino acid residues;
• a third polypeptide that comprises a sequence of amino acid residues selected from the group consisting of:
• (a) IL-2 helix C residues 87-99 of SEQ ID NO:
• 111;
• (b) IL-4 helix C residues 95-118 of SEQ ID NO:
• 112;
• (c) IL-15 helix C residues 107-119 of SEQ ID NO:
• 113;
• (d) GMCSF helix C residues 91-102 of SEQ ID NO:
• 114;
• and
• (e) amino acid residues 92-105 of SEQ ID NO:
• 2;
• a third spacer of 3-29 amino acid residues;
• and
• a fourth polypeptide that comprises a sequence of amino acid residues selected from the group consisting of:
• (a) IL-2 helix D residues 103-121 of SEQ ID NO:
• 111;
• (b) IL-15 helix D residues 134-157 of SEQ ID NO:
• 112;
• (c) IL-4 helix D residues 134-160 of SEQ ID NO:
• 113;
• (d) GMCSF helix D residues 120-131 of SEQ ID NO:
• 114;
• and
• (e) amino acid residues 135-148 of SEQ ID NO:
• 2.