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AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Mark Boldin, Eugene Varfolomeev, Zeev Pancer, Igor Mett, Tanya Goncharov
Estimating the term…
A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.
A modulator of regulatory cellular events occurring intracellularly that are mediated by regulatory proteins containing a ‘death domain’ motif which is a regulatory portion of said proteins, said modulator being capable of interacting with one or more of the ‘death domain’ motifs contained in said regulatory proteins and affecting the regulatory action of one or more of said regulatory proteins.
A method for modulating the concerted intracellular modulation resulting from the indirect interaction between the FAS-R and the p55 TNF-R, via their cascading interaction of MORT-1 and TRADD, or MORT-1 and RIP, comprising, treating cells with a modulator which will enhance or inhibit the MORT-1-TRADD or MORT-1-RIP mediated p55 TNF-R-FAS-R interaction.
Dependencies are inferred from the claim text.