Combination approaches for generating immune responses

A composition for generating an immune response in a mammal, said composition comprising,

• a polynucleotide component comprising two or more polynucleotide sequences comprising coding sequences for two or more analogous HIV immunogenic polypeptides derived from different HIV strains, and
• a polypeptide component comprising one or more HIV immunogenic polypeptides analogous to the polypeptide encoded by said polynucleotide component, with the proviso that, if the polypeptide component comprises the same number or greater than the number of analogous HIV immunogenic polypeptides encoded by the polynucleotide component, then at least one of the HIV immunogenic polypeptides of the polypeptide component is derived from a different HIV strain than the HIV immunogenic polypeptides provided by the polynucleotide component.

A composition for generating an immune response in a mammal, said composition comprising,

• a polynucleotide component comprising two or more polynucleotide sequences comprising coding sequences for two or more analogous HIV immunogenic polypeptides derived from different HIV strains, and
• a polypeptide component comprising one or more HIV immunogenic polypeptides analogous to the analogous polypeptides encoded by said polynucleotide component, with the proviso that at least one of the HIV immunogenic polypeptides of the polypeptide component is derived from a different HIV strain than one of the analogous HIV immunogenic polypeptides provided by the polynucleotide component.

19 to 25. (canceled)

(canceled)

(canceled)

58 to 59. (canceled)

(canceled)

74 to 78. (canceled)

A composition for generating an immune response in a mammal, said composition comprising,

• a polynucleotide component comprising a polynucleotide encoding an HIV immunogenic polypeptide derived from a first HIV strain, and
• a polypeptide component comprising an HIV immunogenic polypeptide analogous to the polypeptide encoded by said polynucleotide component, with the proviso that at least one HIV immunogenic polypeptide of the polypeptide component is derived from a second HIV strain, wherein said first HIV strain and said second HIV strain are different.

(canceled)