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OwnerErnest V. Groman, Christopher P. Reinhardt +1inventors
InventorsErnest V. Groman, Christopher P. Reinhardt, Dennis E. Vaccaro
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Compositions, methods, and functional immunoassays for measuring functioning of organs, receptors, and biological processes in a subject are provided. Functional immunoassay combines pharmacokinetics of xenobiotics after administering one or more of the compositions to a subject by quantifying the xenobiotic in samples taken from the subject. The method provides a xenobiotic that is processed principally by a single organ system with minimal metabolism and involves administering the xenobiotic to the subject, measuring its concentration in samples of biological material obtained over time, calculating a kinetic parameter that describes change in concentration over time, and associating this parameter with the functioning of the target organ. Functional immunoassay is used for measuring, for example, kidney, brain, lung, cardiovascular, gastrointestinal, and immune system function; progression of cancer and infectious disease; and diabetes and inflammatory disease status. Xenobiotics include, for example, drugs, ligands, hormone analogs, substrates, polysaccharides, and nucleic acids and respective analogs.
A composition comprising a first antibody selected from the group comprising anti-iohexol, anti-iothalamate, anti-ioversol, anti-gadolinium-DTPA, anti-gadolinium-DOTA, anti-GdHP-D03A, anti-chromium-EDTA, and anti-inulin;
A composition for determining glomerular filtration rate or effective renal blood flow, wherein the composition comprises at least one antibody that binds at least one xenobiotic selected from the group iohexol, iothalamate, ioversol, gadolinium-DTPA, gadolinium-DOTA, GdHP-D03A, chromium-EDTA, inulin, para-aminohippuric acid, iodohippurate, and mercaptoacetyltriglycine-rhenium (MAG3-Re), wherein determining glomerular filtrations rate or effective renal blood flow is performing an immunoassay with the antibody, thereby determining a concentration of the xenobiotic in at least one post-administration sample from a subject.
An immunizing composition comprising an antigen for producing antibodies to a xenobiotic selected from the group consisting of iohexol, iothalamate, ioversol, GdHP-D03A, chromium-EDTA, inulin, para-aminohippuric acid, iodohippurate, and mercaptoacetyltriglycine-rhenium (MAG3-Re).
A diagnostic kit for quantifying by functional immunoassay a physiological process selected from at least one of glomerular filtration rate, effective renal blood flow, filtration fraction, blood volume, intravascular space, and bile acid activity, the kit comprising a xenobiotic composition, an antibody for the xenobiotic, a detection probe, a container, and instructions for use.
A composition comprising a first xenobiotic selected from the group comprising iohexol, iothalamate, ioversol, gadolinium-DTPA, gadolinium-DOTA, GdHP-D03A, chromium-EDTA, and inulin and a second xenobiotic selected from the group comprising para-aminohippuric acid, iodohippurate and mercaptoacetyltriglycine-rhenium (MAG3-Re).
A method for quantifying at least one physiological process, the method comprising:
A method for quantifying at least one physiological process in a subject, the method comprising:
Dependencies are inferred from the claim text.