Loading patent…
OwnerJean-Christophe Roegel, Pierre Eftekhariinventors
Estimating the term…
The present invention relates to compositions and methods for screening, identifying, or selecting active compounds against a target protein using peptides derived from said target protein's active site(s) and functional antibodies active on said target protein active site(s). The invention also relates to the use of these peptides and functional antibodies for screening, identifying or selecting biologically active compounds. The invention also concerns a kit for implementing the above methods. The target protein is preferably a G-protein-coupled receptor (GPCR), and the invention can be used to identify compounds that are suitable for use in various areas, such as the pharmaceutical, agri-food and cosmetic industries.
1-27. (canceled)
A method for screening, selecting or identifying a molecule active on a target protein, wherein the method comprises contacting a candidate molecule, a functional antibody or functional antibodies and a target molecule having from 5 to 100 amino acid residues in length, wherein the target molecule comprises one or several epitopes of said target protein active site(s) which is/are recognized by said functional antibody or antibodies, and determining whether said candidate molecule inhibits binding of said functional antibody to said target molecule.
A kit for identifying a molecule active on a target protein comprising at least one functional antibody directed against the target protein and a peptide comprising an epitope of said target protein recognized by said antibody.
Dependencies are inferred from the claim text.