Methods for Measuring Therapy Resistance

A method of optimizing therapy for a patient, comprising:

• a) obtaining a genetic sequence of a biological sample from the patient;
• b) identifying a mutation pattern of the genetic sequence of the biological sample, wherein the mutation pattern comprises at least one mutation that correlates to resistance to at least one therapy;
• c) searching a relational genotype/phenotype database for at least one database mutation pattern similar to said mutation pattern of the genetic sequence of the biological sample;
• d) obtaining at least one database phenotype of the at least one database mutation pattern;
• e) determining the phenotype of the biological sample to the therapy from the at least one database phenotype;
• f) repeating steps b) through e) for a group of therapies to obtain a series of phenotypes for the biological sample;
• and
• g) selecting an optimal therapy for the patient from the series of phenotypes.