Markers for breast cancer
AssigneesPerlegen Sciences, Inc., University of Cambridge
InventorsDavid Cox, Dennis Ballinger, Bruce Ponder, Doug Easton
Life of this patent
Estimating the term…
Abstract
Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
Claims34
A method of identifying a breast cancer phenotype for an organism or biological sample derived therefrom, the method comprising:
- detecting, in the organism or biological sample, a polymorphism or a locus closely linked thereto, the polymorphism being selected from a polymorphism of FIGS. 1 or 2, wherein the polymorphism is associated with a breast cancer phenotype;
- and,
- correlating the polymorphism or locus to the phenotype.
A composition comprising a plurality of marker probes or amplification primers that detect or amplify a plurality of polymorphisms selected from:
- SNP ID 2312116, SNP ID 1622530, SNP ID 3712013, SNP ID 1509710, SNP ID 843029, SNP ID 1990126, SNP ID 604819, SNP ID 3025734, SNP ID 1152499, SNP ID 4415909, SNP ID 1732681, SNP ID 4281579, SNP ID 4454457, SNP ID 2616199, SNP ID 1720694, SNP ID 4077723, SNP ID 3711990, SNP ID 3337858, SNP ID 4093095, SNP ID 4213825, SNP ID 3488617, SNP ID 3610210, SNP ID 3451239, SNP ID 1582533, SNP ID 3488150, SNP ID 2770052, SNP ID 4141351, SNP ID 1335030, SNP ID 2211665, and SNP ID 4538418.
A method of identifying a modulator of a breast cancer phenotype, the method comprising:
- contacting a potential modulator to a gene or gene product, wherein the gene or gene product comprises or is closely linked to a polymorphism of selected from SNP ID 2312116, SNP ID 1622530, SNP ID 3712013, SNP ID 1509710, SNP ID 843029, SNP ID 1990126, SNP ID 604819, SNP ID 3025734, SNP ID 1152499, SNP ID 4415909, SNP ID 1732681, SNP ID 4281579, SNP ID 4454457, SNP ID 2616199, SNP ID 1720694, SNP ID 4077723, SNP ID 3711990, SNP ID 3337858, SNP ID 4093095, SNP ID 4213825, SNP ID 3488617, SNP ID 3610210, SNP ID 3451239, SNP ID 1582533, SNP ID 3488150, SNP ID 2770052, SNP ID 4141351, SNP ID 1335030, SNP ID 2211665, and SNP ID4538418;
- and,
- detecting an effect of the potential modulator on the gene or gene product, thereby identifying whether the potential modulator modulates the phenotype.
A system for identifying a breast cancer phenotype for an organism or biological sample derived therefrom, the system comprising:
- a) a set of marker probes or primers configured to detect at least one allele of one or more polymorphism or linked locus, wherein the polymorphism is selected from SNP ID 2312116, SNP ID 1622530, SNP ID 3712013, SNP ID 1509710, SNP ID 843029, SNP ID 1990126, SNP ID 604819, SNP ID 3025734, SNP ID 1152499, SNP ID 4415909, SNP ID 1732681, SNP ID 4281579, SNP ID 4454457, SNP ID 2616199, SNP ID 1720694, SNP ID 4077723, SNP ID 3711990, SNP ID 3337858, SNP ID 4093095, SNP ID 4213825, SNP ID 3488617, SNP ID 3610210, SNP ID 3451239, SNP ID 1582533, SNP ID 3488150, SNP ID 2770052, SNP ID 4141351, SNP ID 1335030, SNP ID 2211665, and SNP ID 4538418;
- b) a detector that is configured to detect one or more signal outputs from the set of marker probes or primers, or an amplicon produced from the set of marker probes or primers, thereby identifying the presence or absence of the allele;
- and,
- c) system instructions that correlate the presence or absence of the allele with a predicted phenotype.
Dependencies are inferred from the claim text.