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AssigneeThe General Hospital Corporation
InventorsRobert Burgeson, Manuel Koch, Douglas Keene, William Brunken, Leena Bruckner-Tuderman
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The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a collagen XXII gene has been introduced or disrupted. The invention still further provides isolated collagen XXII proteins, fusion proteins, antigenic peptides and anti-collagen XXII antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
1-35. (canceled)
An isolated polypeptide comprising an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence selected from the group consisting of:
An isolated polypeptide encoded by a nucleotide sequence at least 80% identical to the nucleotide sequence of SEQ ID NO:3.
An isolated polypeptide encoded by a nucleic acid comprising a nucleotide sequence more than 500 nucleotides in length that hybridizes under highly stringent conditions, comprising 6×SSC at 45° C., followed by one wash in 0.2×SSC, 0.1% SDS at 65° C., to a nucleotide sequence consisting of SEQ ID NO:1 or 3, or the complement of SEQ ID NO:1 or 3, wherein the polypeptide has one or more of the following activities:
An antigenic fragment of SEQ ID NO:2.
Dependencies are inferred from the claim text.