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US 2007/0166697 A1Published application
Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo
AssigneeApplera Corporation
InventorSteven Menchen
Life of this patent
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Abstract
Cross-linked hydrophilic nanocapsules and various compositions and methods for their preparation and use are provided.
Claims54
A reverse micelle comprising:
- a plurality of amphiphilic polymers, wherein each polymer, independently from the others, comprises the structure:
- wherein
- (A—B)l represents a monomer unit comprising a first polymer block moiety;
- [—(E—F)n—(G—H)o—] each independently of the other, represents monomer units comprising a second polymer block moiety;
- (C—D)m represents a linker moiety;
- R1, R2, R3, R4 represent optional substituents;
- R5—R6—R7 represent a first functional group, R8—R9—R10 represent a second functional group, R11—R12 represent a third fuinctional group, and R13—R14 represent a fourth fuinctional group;
- and,
- l and n represent integers from 4-20, m represents an integer from 0 to 1, and o represents an integer from 2 to 6.
6 more elements
A reverse micelle according to claim 14 in which the R7 and/or the R10 substituent is cleavable to yield the water insoluble monomer unit (E—F) comprising at least one water soluble functional group comprising R5—R6, and/or R8—R9.
A cross-linked hydrophilic nanocapsule comprising:
- a water soluble reporter system, wherein the nanocapsule is impermeable to the diffusion of the reporter system out of the nanocapsule, and a plurality of hydrophilic polymers.
An amphiphilic polymer comprising the structure:
- wherein
- (A—B)l represents a monomer unit comprising a first polymer block moiety;
- [—(E—F)n—(G—H)o—] each independently of the other, represents monomer units comprising a second polymer block moiety;
- (C—D)m represents a linker moiety;
- R1, R2, R3, R4 represent optional substituents;
- R5—R6—R7 represent a first functional group, R8—R9—R10 represent a second functional group, R11 —R12 represent a third functional group, and R13—R14 represent a fourth functional group;
- and,
- l and n represent integers from 4-20, m represents an integer from 0 to 1, and o represents an integer from 2 to 6.
5 more elements
Dependencies are inferred from the claim text.