Composition and method to increase mammalian sperm function
OwnerTod McCauley, Huanmin Zhang +1inventors
InventorsTod McCauley, Huanmin Zhang, Roy Ax
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Abstract
A composition of matter for increasing the motility and/or percentage of intact acrosomes (PIA) in sperm is described. The composition includes, in combination, an amount of FAA and an amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm contacted with the composition. The composition can be used as a cryopreservation medium for sperm.
Claims28
A composition of matter for increasing motility or percentage of intact acrosomes (PIA) in sperm, the composition comprising, in combination, an amount of FAA and an amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm contacted with the composition.
A method to improve the functionality of sperm, the method comprising
- (a) contacting sperm with a composition of matter comprising, in combination, an exogenous amount of FAA and an exogenous amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm contacted with the composition.
A kit for increasing motility or percentage of intact acrosomes (PIA) in sperm, the kit comprising, in combination:
- a composition of matter disposed in a suitable container, the composition comprising an amount of FAA and an amount of TIMP-2, wherein the composition is disposed in a suitable container, and wherein the amounts are effective, in combination, to increase the motility, the PIA, or the motility and the PIA of sperm contacted with the composition;
- and
- instructions for use of the kit.
Dependencies are inferred from the claim text.