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OwnerThomas Dobbertin, Wolfgang Kowalsky +2inventors
InventorsThomas Dobbertin, Wolfgang Kowalsky, Hans-Hermann Johannes, Eike Becker
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The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R1=—H, —NH2, —Br, —Cl, —OH, —COOH, B=—N═, —CH═, Z=—CH═, —N═, A=—N═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—N═, A=—CH═ at B=—CH═, Z=—CH═, A=—CH═ at B=—CH═, Z=—N═, and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.
The use of a layer (HIL 1) composed of a hydrophobic, linearly or two-dimensionally polycyclic aromatic having from 3 to 12 ring structures including metal-containing or metal-free phthalocyanines, which have, as radical groups, —H and/or —F, alkyl groups, aryl groups and/or fluorinated hydrocarbons, as a barrier layer in or as an encapsulation of electrical components constructed with organic layers.
An organic light-emitting diode having a substrate, a first electrode applied to the substrate, at least one electron-injecting and -transporting zone (EIL), at least one hole-injecting and -transporting zone (HTL, HIL) and a second electrode wherein the hole-injecting and -transporting zone includes a layer composed of polycyclic aromatics having linear or two-dimensional chains and from 3 to 12 ring structures including metal-containing or metal-free phthalocyanines, which have, as radical groups, —H and/or —F, alkyl groups, aryl groups, and or fluorinated hydrocarbons, said layer being in the form of an encapsulation layer.
An organic light-emitting diode having a substrate, a cathode applied to the substrate, at least one electron-injecting and -transporting zone (EIL), at least one hole-injecting and -transporting zone (HTL, HIL), and a light-transparent anode wherein the electron-injecting and -transporting zone (EIL) is constructed with small molecules, and wherein said electron-injecting and -transporting zone (EIL) is adjoined toward the anode by a layer composed of polycyclic aromatics having linear or two-dimensional chains and from 3 to 12 ring structures including metal-containing or metal-free phthalocyanines, which includes, as radical groups —H and/or —F, alkyl groups, aryl groups and/or fluorinated hydrocarbons.
Dependencies are inferred from the claim text.