Treatment modalities for autoimmune diseases
AssigneeMetaproteomics, LLC
InventorsMatthew Tripp, Jeffrey Bland, Robert Lerman, Amy Hall, Veera Konda, Anu Desai
Life of this patent
Estimating the term…
Abstract
Compositions of reduced isoalpha acids, vitamins and minerals are disclosed as well as methods of using the same for the treatment of autoimmune diseases. Additional combinations including other compounds are also contemplated. Synergistic properties and methods exploiting such synergy are also disclosed.
Claims31
A composition comprising at least one reduced isoalpha acid compound, a mineral, and a vitamin.
A composition comprising:
- (a) at least one compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone;
- (b) at least one compound of a supragenus having the formula:
- wherein R′ is selected from the group consisting of carbonyl, hydroxyl, OR, and OCOR, wherein R is alkyl;
- wherein R″ is selected from the group consisting of CH(CH3)2, CH2CH(CH3)2, and CH(CH3)CH2CH3;
- and
- wherein R, T, X, and Z are independently selected from the group consisting of H, F, Cl, Br, I, and π orbital, with the proviso that if one of R, T, X, or Z is a π orbital, then the adjacent R, T, X, or Z is also a π orbital, thereby forming a double bond;
- (c) a vitamin;
- and
- (d) a mineral.
A composition comprising:
- (a) at least one compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone;
- (b) at least one compound of Genus A having the formula:
- wherein R′ is selected from the group consisting of carbonyl, hydroxyl, OR, and OCOR, wherein R is alkyl;
- and
- wherein R″ is selected from the group consisting of CH(CH3)2, CH2CH(CH3)2, and CH(CH3)CH2CH;
- (c) a vitamin;
- and
- (d) a mineral.
A composition comprising:
- (a) at least one compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone;
- (b) is a compound of Genus B having the formula:
- wherein R′ is selected from the group consisting of carbonyl, hydroxyl, OR, and OCOR, wherein R is alkyl;
- and
- wherein R″ is selected from the group consisting of CH(CH3)2, CH2CH(CH3)2, and CH(CH3)CH2CH3;
- (c) a vitamin;
- and
- (d) a mineral.
A method of treating an autoimmune disease comprising the step of administering to a mammal a therapeutically effective amount of a composition comprising at least one reduced isoalpha acid compound, a mineral, and a vitamin.
The method of claim 18, wherein the autoimmune disease is selected from the group consisting of alopecia areata, ankylosing spondylitis, arthritis, antiphospholipid syndrome, autoimmune Addison's disease, autoimmune hemolytic anemia, autoimmune inner ear disease (also known as Meniers disease), autimmune lymphoproliferative syndrome (ALPS), autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia, autoimmune hepatitis, Bechet's disease, Crohn's disease, diabetes mellitus type 1, glomerulonephritis, Graves' disease, Guillain-Barré syndrome, inflammatory bowel disease, lupus nephritis, multiple sclerosis, myasthenis gravis, pemphigus, pernicous anemia, polyarteritis nodosa, polymyositis, primary billiary cirrhosis, psoriasis, Raynaud's Phenomenon, rheumatic fever, rheumatoid arthritis, scleroderma, Sjögren's syndrome, systemic lupus erythematosus, ulcerative colitis, vitiligo, and Wegener's granulamatosis.
The method of claim 18, wherein the autoimmune disease is selected from the group consisting of Crohn's disease, Raynaud's Phenomenon, rheumatoid arthritis, and systemic lupus erythematosus.
Dependencies are inferred from the claim text.