Biocompatible tissue graft material for implant and method of making
AssigneeBrennen Medical, Inc.
InventorsLeo Katzner, Phillip Lawin
Life of this patent
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Abstract
This invention provides an antigen-free and immunologically inert tissue graft material and methods of preparing and using these tissue graft materials.
Claims25
A method of preparing an absorbable remodelable graft material that is antigen-free and immunologically inert in which an animal tissue is soaked in a bleach solution;
- washed in a detergent solution;
- rinsed to remove the detergent solution;
- configured to a desired physical form and thickness;
- soaked in an iodophor solution;
- rinsed to remove the iodophor solution;
- soaked in a hypertonic solution;
- rinsed to remove the hypertonic solution;
- wherein the method comprises:
- (a) agitating the animal tissue in a mixture of a caustic and peroxide solution to provide an antigen-free animal tissue;
- and
- (b) rinsing the antigen-free animal tissue in water.
An implantable material comprising:
- a substantially hair-free, endotoxin-free and immunologically inert tissue material that has a thickness of about 0.02-0.1 inches, and that is bioabsorbable and remodelable.
A method of preparing an absorbable remodelable graft tissue material that is hairless and immunologically inert comprising the steps of:
- (a) soaking an animal tissue in a bleach solution;
- (b) washing the animal tissue in a detergent solution;
- (c) rinsing the animal tissue to remove the detergent solution;
- (d) configuring the animal tissue to a desired physical form and thickness;
- (e) soaking the animal tissue in an iodophor solution;
- (f) rinsing the animal tissue to remove the iodophor solution;
- (g) soaking the animal tissue in a h48ypertonic solution;
- (h) rinsing the animal tissue to remove the hypertonic solution;
- (i) agitating the animal tissue in a mixture of a caustic and peroxide solution;
- and
- (j) rinsing the animal tissue in water to remove the mixture of caustic and peroxide solution.
A method of preparing an endotoxin-free, antigen-free and immunologically inert implantable material that is absorbable and remodeable comprising the steps of lysing tissue using an osmotic pressure gradient followed by removal of remaining immunological components by treating the tissue with a caustic peroxide solution followed by a rinse to remove residuals.
An implantable graft material comprising:
- an endotoxin-free, antigen-free and immunologically inert implantable graft material that is configured to a shape and thickness to delay bioabsorption or remodeling and to increase resistance to enzymatic degradation.
A method of implanting a graft material comprising:
- (a) providing an endotoxin-free, antigen-free and immunologically inert implantable graft material that is configured to a shape and thickness to delay bioabsorption or remodeling and to increase resistance to enzymatic degradation;
- and
- (b) implanting the graft material within the body.
Dependencies are inferred from the claim text.