Combinations and modes of administration of therapeutic agents and combination therapy
OwnerNeil Desai, Patrick Soon-Shionginventors
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Abstract
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
Claims39
A method of treating a proliferative disease in an individual, comprising administering to the individual:
- a) an effective amount of a composition comprising nanoparticles comprising taxane and a carrier protein, and b) an effective amount of an anti-VEGF antibody.
A method of inhibiting tumor metastasis in an individual, comprising administering to the individual:
- a) an effective amount of a composition comprising nanoparticles comprising taxane and a carrier protein, and b) an effective amount of an anti-VEGF antibody.
Dependencies are inferred from the claim text.