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US 2007/0166386 A1Published application
Nanoparticle formation of pharmaceutical ingredients
OwnerVanessa Chinea, Kevin Kane +2inventors
InventorsVanessa Chinea, Kevin Kane, Isaac Farr, Iddys Figueroa
Life of this patent
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Abstract
A pharmaceutical ingredient is dissolved within a solvent. The solvent is evaporated until nanoparticles of the pharmaceutical ingredient are at least partially formed without employing a substrate for them. A portion of the solvent remains, within which the nanoparticles are located.
Claims34
A method comprising:
- dissolving a pharmaceutical ingredient within a solvent;
- and,
- evaporating the solvent until a plurality of nanoparticles of the pharmaceutical ingredient are at least partially formed without employing a substrate for the nanoparticles,
- such that a portion of the solvent remains within which the nanoparticles are located.
1 more element
A plurality of nanoparticles of a pharmaceutical ingredient formed by performing a method comprising:
- evaporating a solvent within which the pharmaceutical ingredient has been dissolved until the nanoparticles of the pharmaceutical ingredient are formed, without employing a substrate for the nanoparticles;
- and,
- at least substantially reducing or stopping evaporation of the solvent within which the nanoparticles have been formed to prevent degradation of the nanoparticles.
A plurality of nanoparticles of a pharmaceutical ingredient formed by performing a method comprising:
- evaporating a solvent within which the pharmaceutical ingredient has been dissolved, resulting in a reduction in volume of the solvent and cooling of the solvent;
- and,
- adding anti-solvent in vapor form such that the anti-solvent precipitates in relation to the solvent within which the pharmaceutical ingredient has been dissolved,
- where evaporation of the solvent and addition of the anti-solvent results in formation of the nanoparticles without employing a substrate for the nanoparticles.
1 more element
Dependencies are inferred from the claim text.