Bioresponsive polymer system for delivery of microbicides
OwnerPatrick Kiser, David Katz +1inventors
InventorsPatrick Kiser, David Katz, Russell Stewart
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Abstract
The polymer systems of the present invention degrade in the presence of an ejaculate. They may further provide degradable sequences that degrade upon contact with an ejaculate and/or microbicides. The polymer systems of the present invention are of use in the oral, rectal or vaginal cavities of an individual for such purposes as the treatment or prevention of sexually transmitted disease, the prevention or promotion of fertility or for hormone replacement therapy.
Claims30
A composition comprising;
- a polymer system susceptible to degradation upon exposure to an ejaculate.
A method comprising;
- administering to an individual a polymer system susceptible to degradation upon exposure to an ejaculate.
A method for delivering microbicides to an individual upon exposure to an ejaculate, said method comprising;
- (a) providing a polymer system susceptible to degradation upon exposure to an ejaculate, wherein said polymer system contains microbicides to be released upon degradation, and
- (b) contacting said polymer system to a cavity selected from the group consisting of the oral, vaginal and anal cavities.
A composition comprising;
- a polymer system wherein upon application to a cavity selected from the group consisting of oral, vaginal and anal cavities, the composition forms a gel susceptible to degradation upon exposure to an ejaculate.
A polymer system comprising;
- two polymers wherein one polymer contains α-hydroxy acids susceptible to degradation upon an increase in pH upon exposure to an ejaculate wherein said polymer system experiences a reduction in viscosity in response to said increase in pH.
A polymer system comprising;
- one or more polymers sensitive to alterations in pH wherein at an average pH found in the vaginal cavity said polymer system is a gel and wherein at an average pH found in the presence of an ejaculate, said polymer system experiences a reduction in viscosity.
A polymer system comprising;
- one or more polymers connected by crosslinking wherein said crosslinking is susceptible to degradation upon exposure to an ejaculate.
A composition comprising;
- a polymer system susceptible to degradation by an ejaculate, said degradation of the type selected from the group consisting of chemical, physical and enzymatic.
Dependencies are inferred from the claim text.