Pre-fabricated semi-permeable capsule shells containing a semipermeable layer on a water-dispersible/soluble gelatinous shell for osmotic drug delivery system
OwnerHasmukh Patelinventor
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Abstract
The present invention is centered on the design, manufacturing and use of a novel capsule system made up of a bi- or multi-layered two piece capsule shell made of a water soluble/dispersible layer coated with water-insoluble semi-permeable membrane capsule shell. The therapeutic agent is formulated in the drug layer and the osmotic layer is compacted together. The osmotic layer is a rate controlling agent. This compacted core is then inserted in the body of the layered body followed by encapping with a layered cap (which is pre-drilled or drilled after inserting the core) followed by applying a sealing agent as a band where the body and the cap of capsule meet.
Claims9
Bi- and multi-layered hard shells made of two parts a body and a telescopically fitting cap where the composition of the shell's outer layer is a water insoluble semi-permeable membrane and the inner layer is made up of a natural, synthetic or semi-synthetic, gelatinous water soluble or dispersible polymer as shown in Drawing FIG. 1 for osmotic drug delivery with core tablet made of an osmotic layer and one or more drug or nutrient layers.
Dependencies are inferred from the claim text.