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US 2007/0166367 A1Published application
Adept or gdept producing acetaldehyde
OwnerPhilip Savageinventor
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Abstract
The present invention includes compounds, comprising a portion capable of converting a substrate, for example ethanol, to acetaldehyde and a means of directing the compounds to selected cells, and their use in therapeutic compositions and methods. The compounds may be administered with the substrate, for example ethanol, and an inhibitor of aldehyde dehydrogenase.
Claims37
A method of damaging target cells in a subject, the method comprising administering to the subject
- (1) a nucleic acid encoding a compound capable of converting a substrate to acetaldehyde, wherein said compound is an enzymatically active portion of alcohol dehydrogenase;
- and
- (2) a substrate which is converted to acetaldehyde by the portion capable of converting said substrate to acetaldehyde;
- wherein said substrate is ethanol.
1 more element
(canceled)
A method of treating cancer comprising administering ethanol or pyruvate to a subject in need thereof.
(canceled)
(canceled)
Dependencies are inferred from the claim text.