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AssigneeStryker Corporation
InventorsHermann Oppermann, Engin Ozkaynak, Thangavel Kuberasampath, David Rueger, Roy Pang
Estimating the term…
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
1-19. (canceled)
A DNA sequence encoding a protein capable of inducing endochonral bone formation in a mammal when disulfide bonded to form a dimeric species and implanted together with a matrix in said mammal and comprising at least one of the following amino acid sequences:
The protein comprising the amino acid sequence described by residues 335 to 431 of Seq. ID No. 1 (OPS).
32-37. (canceled)
The protein comprising the amino acid sequence described by residues 306 to 402 of Seq ID No. 28.
45-133. (canceled)
Dependencies are inferred from the claim text.