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OwnerDavid Delmarre, Ajit Narang +5inventors
InventorsDavid Delmarre, Ajit Narang, Kaidi Zhao, Meagan Weldele, Barbara Chen, Carlos-Julian Centeno, Danchen Gao
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The present invention is directed to improved oral liquid compositions that include sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition. The compositions are substantially free of oxidation impurities. Typically, the compositions include a sweetening agent and a flavoring agent, or a bitterness-reducing agent and flavoring agent. Processes of preparing such compositions and methods of administering such compositions are also included.
An oral liquid composition comprising sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that provides a liquid portion of the composition and is selected to minimize formation of one or more oxidation impurities, wherein the composition is substantially free of at least one of the oxidation impurities after storage for at least about one month at 40° C.
An oral liquid composition comprising sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition and comprises a sweetening agent and a flavoring agent that provides a mint flavor, the sweetening agent and flavoring agent included in amounts sufficient to collectively minimize or mask the bitterness of the sumatriptan.
A method of preparing an oral liquid sumatriptan composition which comprises:
An oral liquid composition comprising sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition and comprises a bitterness-reducing agent and a flavoring agent.
Dependencies are inferred from the claim text.