Methods for preventing flavivirus infection
AssigneesThe Govt. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services, Centers for Disease Control and Prevention
InventorGwong-Jen Chang
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Abstract
The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection.
Claims20
A method of immunizing a subject against infection by a flavivirus, comprising administering to the subject an effective amount of a composition comprising:
- an isolated nucleic acid comprising a transcriptional unit encoding an engineered Japanese Encephalitis Virus (JEV) signal sequence, which engineered JEV signal sequence comprises SEQ ID NO:14, and an immunogenic flavivirus antigen of a flavivirus other than JEV, wherein the transcriptional unit directs the synthesis of the immunogenic flavivirus antigen;
- and
- a pharmaceutically acceptable carrier.
An isolated antibody produced by administering to a subject an effective amount of a composition comprising:
- an isolated nucleic acid comprising a transcriptional unit encoding an engineered Japanese Encephalitis Virus (JEV) signal sequence, which engineered JEV signal sequence comprises SEQ ID NO:14, and an immunogenic flavivirus antigen of a flavivirus other than JEV, wherein the transcriptional unit directs the synthesis of the immunogenic flavivirus antigen;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.